TY  - JOUR
AU  - Choosit, Sawapat 
AU  - Wattanapermpool, Jonggonnee 
AU  - Bupha-Intr, Tepmanas 
PY  - 2021/08/27
Y2  - 2026/03/01
TI  - Myocardial Expression of Heart-Type Fatty Acid Binding Protein (h-FABP) in Various Cardiac Stress Conditions in Rats
JF  - Asian Medical Journal and Alternative Medicine
JA  - AMJAM
VL  - 21
IS  - 2
SE  - Original Articles
DO  - 
UR  - https://asianmedjam.com/index.php/amjam/article/view/265
SP  - 97-105
AB  - &lt;p&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The heart-type fatty acid binding protein (h-FABP) has recently been studied as the specific biomarker of myocardial injury. The present study aimed to investigate the potential stress conditions that affect the expression of h-FABP in the rat heart.&lt;br&gt;&lt;strong&gt;Methods:&lt;/strong&gt; Immunoblot analysis was used to quantify the protein expression of h-FABP in the heart under various cardiac stress conditions, including the effect of an aerobic training program, deprivation of ovarian sex hormones, angiotensin II-induced hypertension, doxorubicininduced cardiotoxicity, and type II diabetes.&lt;br&gt;&lt;strong&gt;Results:&lt;/strong&gt; No significant change in h-FABP protein expression in the heart was found after a 9-week exercise training compared to sedentary controls. Lack of female sex hormones for 10 weeks also had no effect on h-FABP protein expression. In addition, there was no change in h-FABP expression due to either 4-week angiotensin II infusion or doxorubicin treatment compared to their vehicle controls. A significant increase in h-FABP was demonstrated in the heart of spontaneous diabetes Torii (SDT) rats compared to those without diabetes (&lt;em&gt;P&lt;/em&gt;-value &amp;lt; 0.0001). There was a high correlation between degree of hyperglycemia and the myocardial expression of h-FABP protein (r&lt;sup&gt;2&lt;/sup&gt; = 0.9252,&lt;em&gt; P&lt;/em&gt;-value = 0.0022).&lt;br&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; The findings suggest that the expression of h-FABP in the heart is primarily regulated by available sources of energy, while cardiac hypertrophy and myocardial damage do not particularly contribute to h-FABP expression.&lt;/p&gt;
ER  -