TY  - JOUR
AU  - Vo , Thanh Tri
AU  - Le , Thi Hoang My
AU  - Trinh , Thi Hong Cua
AU  - Pham,  Thi Ngoc Nga
AU  - Tran,  Phuoc Thinh
AU  - Phan,  Hoang Dat, B.Sc.
AU  - Nguyen,  Phuc Duc,
AU  - Nguyen,  Chi Nguyen
AU  - Vo,  Thai Duong
PY  - 2023/04/27
Y2  - 2026/03/01
TI  - Common alpha globin deletion mutation spectrum in hemoglobin H disease patients in the Mekong Delta, Vietnam
JF  - Asian Medical Journal and Alternative Medicine
JA  - AMJAM
VL  - 23
IS  - 1
SE  - Original Articles
DO  - 
UR  - https://asianmedjam.com/index.php/amjam/article/view/1292
SP  - 9-16
AB  - &lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Hemoglobin H disease is a type of α-thalassemia brought on by a shortage in the generation of hemoglobin globin chains (Hb). The patients produce a form of hemoglobin called hemoglobin H by inactivation of three α-globin genes. In this paper, we report the presence of the four deletion mutations of Southeast Asia in hemoglobin H disease patients in the&lt;br /&gt;Mekong Delta, Vietnam.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods:&lt;/strong&gt; DNA from 50 hemoglobin H disease patients were extracted from EDTA-anticoagulated whole blood and screened for the four common α-globin deletion mutations using Gap-Polymerase Chain Reaction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results:&lt;/strong&gt; The most common type of deletion was --SEA deletion, accounting for 73.5% of the mutant alleles, followed by the -α3.7 (rightward) deletion (19.1%) and -α4.2 (leftward) deletion (7.4%) mutation in this region. In this study, the --THAI mutation was not detected.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; This study gave an overview of the prevalence of typical α-globin gene mutations in Vietnam and might act as a starting point for a further research into these genetic flaws.&lt;/p&gt;
ER  -