@article{Choosit_Wattanapermpool_Bupha-Intr_2021, title={Myocardial Expression of Heart-Type Fatty Acid Binding Protein (h-FABP) in Various Cardiac Stress Conditions in Rats}, volume={21}, url={https://asianmedjam.com/index.php/amjam/article/view/265}, abstractNote={<p><strong>Objective:</strong> The heart-type fatty acid binding protein (h-FABP) has recently been studied as the specific biomarker of myocardial injury. The present study aimed to investigate the potential stress conditions that affect the expression of h-FABP in the rat heart.<br><strong>Methods:</strong> Immunoblot analysis was used to quantify the protein expression of h-FABP in the heart under various cardiac stress conditions, including the effect of an aerobic training program, deprivation of ovarian sex hormones, angiotensin II-induced hypertension, doxorubicininduced cardiotoxicity, and type II diabetes.<br><strong>Results:</strong> No significant change in h-FABP protein expression in the heart was found after a 9-week exercise training compared to sedentary controls. Lack of female sex hormones for 10 weeks also had no effect on h-FABP protein expression. In addition, there was no change in h-FABP expression due to either 4-week angiotensin II infusion or doxorubicin treatment compared to their vehicle controls. A significant increase in h-FABP was demonstrated in the heart of spontaneous diabetes Torii (SDT) rats compared to those without diabetes (<em>P</em>-value < 0.0001). There was a high correlation between degree of hyperglycemia and the myocardial expression of h-FABP protein (r<sup>2</sup> = 0.9252,<em> P</em>-value = 0.0022).<br><strong>Conclusion:</strong> The findings suggest that the expression of h-FABP in the heart is primarily regulated by available sources of energy, while cardiac hypertrophy and myocardial damage do not particularly contribute to h-FABP expression.</p>}, number={2}, journal={Asian Medical Journal and Alternative Medicine}, author={Choosit, Sawapat and Wattanapermpool, Jonggonnee and Bupha-Intr, Tepmanas}, year={2021}, month={Aug.}, pages={97–105} }