@article{Chaiyawathanananthn_2023, title={Recipe 2, A Thai Herbal Remedy in Worayokasarn Scripture, for reducing obesity}, volume={23}, url={https://asianmedjam.com/index.php/amjam/article/view/1455}, abstractNote={<p style="font-weight: 400;">Recipe 2 is a Thai herbal medical remedy for treating obesity in Worayokasarn scripture.  The recipe consists of three plants i.e., <em>Terminalia chebula</em> Retz. (Sa-Mor-Thai) fruits, <em>Cyperus rotundus</em> L. (Hua-Haw-Mhoo) rhizomes, <em>Tinospora crispa</em> (L.) Miers ex Hook. f. & Thomson or <em>Tinospora cordifolia</em> (Thunb.) Miers (Bo-Ra-Pet) vines.<sup>1</sup> The three herbal ingredients of the remedy showed anti-obese effects by reducing lipid accumulation and lipogenesis.  The ethanolic extract of <em>T. chebula</em> fruit decreased lipogenesis in obese mice by reducing fatty acid synthase, increasing fatty acid oxidation through peroxisome proliferator-activated receptors α (PPARα) and carnitine palmitoyltransferase-1 (CPT-1).<sup>2</sup>  After 14 days of treatments, Haritaki or <em>T. chebula</em> at 1.05 and 2.10 mg/kg body weight (b.w.) concentrations reduced total cholesterol (TC) and total triglycerides (TG) in hyperlipidemia-induced Wistar rats with atherogenic diet.<sup>3</sup>  Majeed M, et. al., presented Piceatannol, Scirpusin A and Scirpusin B in the <em>C. rotundus</em> rhizome extract reduced adipogenesis in 3T3-L1 adipocytes.<sup>4</sup>  450 mg/kg concentrations of aqueous <em>T. crispa</em> extract in 0.5% cholesterol chow diet-inducing New Zealand White rabbits showed effect in reducing blood serum TC, TG and low density lipoprotein-cholesterol (LDL-C) levels and increasing high density lipoprotein-cholesterol (HDL-C) level.<sup>5</sup> After feeding of high fat diet in rats for 12 weeks leading to the development of obesity, the obesity rats receiving <em>T. cordifolia</em>stem powder at 1 mg/g b.w. for 12 weeks subsided body weight, adiposity index, serum cholesterol, and serum triglyceride.<sup>6</sup></p> <p><span style="font-weight: 400;">These scientific studies presented anti-obese effect of the herbal ingredients of the remedy by reducing lipid accumulation and serum lipids.</span><span style="font-weight: 400;">  </span><span style="font-weight: 400;">This remedy may be effect to reduce obesity and lipid profile following a Thai traditional medical theory.</span></p>}, number={3}, journal={Asian Medical Journal and Alternative Medicine}, author={Chaiyawathanananthn, Pannawat}, year={2023}, month={Dec.}, pages={7–8} }