@article{Phumlek_Itharat_Lee_Pongcharoen_Moon_Chakkavittumrong_Davies_2022, title={Hydrogel Patch Containing Mangosteen Ethanolic Extract and Its Clinical Safety for Acne Vulgaris Treatment}, volume={22}, url={https://asianmedjam.com/index.php/amjam/article/view/1324}, abstractNote={<p><strong>Introduction:</strong> <em>Garcinia mangostana</em>, simply known as mangosteen, has long been used as Thai traditional medicine because it was reported antibacterial and anti-inflammatory activities for skin infection treatment. <br /><strong>Objectives:</strong> This study aims to develop mangosteen pericarps into a hydrogel patch against acne-inducing bacteria and evaluate its clinical safety.<br /><strong>Methods:</strong> The hydrogel patch containing mangosteen ethanolic extract was investigated for antibacterial activity against <em>Cutibacterium acnes</em>, <em>Staphylococcus epidermidis</em>, and <em>Staphylococcus </em><em>aureus</em>. Its mechanical properties, <em>in vitro</em> release, skin permeation, and phase I clinical study of skin irritation and allergic testing by closed patch test were also investigated.<br /><strong>Results:</strong> The mangosteen hydrogel patch made from carrageenan and locust bean gum powders was a yellow patch that is smooth, durable, and flexible. This patch was effectively against <em>Cutibacterium acnes</em>, <em>Staphylococcus epidermidis</em>, and <em>Staphylococcus aureus</em>. The active ingredient, α-mangostin, was released and permeated from the mangosteen hydrogel patch within the first 30 min at 33.16% and 32.96%, respectively. Mangosteen ethanolic extract and hydrogel patch showed no irritation in 30 healthy volunteers. However, two volunteers (6.67%) had delayed allergic contact dermatitis to 2-5% mangosteen ethanolic extract and 0.5% (w/w) mangosteen hydrogel patch. <br /><strong>Conclusions:</strong> This hydrogel patch containing mangosteen ethanolic extract could be considered as an anti-acne facial mask. Nevertheless, it is not recommended for people who have any reaction to mangosteen.</p>}, number={-}, journal={Asian Medical Journal and Alternative Medicine}, author={Phumlek, Kalyarut and Itharat, Arunporn and Lee, Hyang-Yeol and Pongcharoen, Padcha and Moon, Gi-Seong and Chakkavittumrong, Panlop and Davies, Neal M.}, year={2022}, month={Aug.}, pages={S136} }