@article{Srichareonchai_Songrin_2022, title={Association Between ROX Index and Outcomes of High Flow Nasal Cannula in Post-extubated Patients}, volume={22}, url={https://asianmedjam.com/index.php/amjam/article/view/1299}, abstractNote={<p><strong>Introduction: </strong>High flow nasal cannula (HFNC) therapy is widely used in post-extubated patients. However, no standard parameter is available to predict the outcomes of HFNC during the post-extubated period. The ratio of oxygen saturation (ROX) index is used to predict HFNC failure in acute hypoxemic respiratory failure patients but there is insufficient evidence for use in post-extubated period.</p> <p><strong>Objectives:</strong> To evaluate ROX index as a parameter to anticipate outcomes of HFNC in post-extubated patients.</p> <p><strong>Methods:</strong> Cross-sectional study by Retrospective chart review was performed to investigate the role of ROX index in predicting outcomes of HFNC in post-extubated patients, i.e., successful extubation, 28 - day and hospital mortality, hospital length of stay (LOS). Baseline characteristics, respiratory and hemodynamic data were collected 6 hours before; and 2 - 6 hours, 6 - 12 hours, and 12 - 24 hours after HFNC application, subsequently the ROC analysis was performed.</p> <p><strong>Results:</strong> Of 236 patients, 196 (83%) and 40 (17%) succeeded and failed extubation after HFNC use respectively.At 6 - 12 hours of HFNC use, the mean ± SD of ROX indices forsucceeded and failed groups were 12.66 ± 1.89 and 6.71 ± 1.44 (breath/min)<sup>-1</sup>, respectively and the ROX index cut-off value of 9.4 (breath/min)<sup>-1</sup> (AUROC = 0.991, 95% CI = 0.980-1.000) was strongly associated with successful extubation of HFNC application during post-extubated period. Higher ROX index at 2 - 6 hours of HFNC was associated with lower 28-day and hospital mortality, and shorter hospital LOS. <strong>Conclusions:</strong> ROX index can be a tool to predict outcomes of HFNC use in post-extubation period, with ROX index 9.4 (breath/min)<sup>-1</sup> at 6 - 12 hours of HFNC use associated with successful extubation.</p>}, number={-}, journal={Asian Medical Journal and Alternative Medicine}, author={Srichareonchai, Thiti and Songrin, Metanee}, year={2022}, month={Aug.}, pages={S97} }