@article{Vo_Le_Trinh_Pham_Tran_Phan_Nguyen_Nguyen_Vo_2023, title={Common alpha globin deletion mutation spectrum in hemoglobin H disease patients in the Mekong Delta, Vietnam}, volume={23}, url={https://asianmedjam.com/index.php/amjam/article/view/1292}, abstractNote={<p><strong>Introduction:</strong> Hemoglobin H disease is a type of α-thalassemia brought on by a shortage in the generation of hemoglobin globin chains (Hb). The patients produce a form of hemoglobin called hemoglobin H by inactivation of three α-globin genes. In this paper, we report the presence of the four deletion mutations of Southeast Asia in hemoglobin H disease patients in the<br />Mekong Delta, Vietnam.</p>
<p><strong>Methods:</strong> DNA from 50 hemoglobin H disease patients were extracted from EDTA-anticoagulated whole blood and screened for the four common α-globin deletion mutations using Gap-Polymerase Chain Reaction.</p>
<p><strong>Results:</strong> The most common type of deletion was --SEA deletion, accounting for 73.5% of the mutant alleles, followed by the -α3.7 (rightward) deletion (19.1%) and -α4.2 (leftward) deletion (7.4%) mutation in this region. In this study, the --THAI mutation was not detected.</p>
<p><strong>Conclusions:</strong> This study gave an overview of the prevalence of typical α-globin gene mutations in Vietnam and might act as a starting point for a further research into these genetic flaws.</p>}, number={1}, journal={Asian Medical Journal and Alternative Medicine}, author={Vo , Thanh Tri and Le , Thi Hoang My and Trinh , Thi Hong Cua and Pham, Thi Ngoc Nga and Tran, Phuoc Thinh and Phan, Hoang Dat, B.Sc. and Nguyen, Phuc Duc, and Nguyen, Chi Nguyen and Vo, Thai Duong}, year={2023}, month={Apr.}, pages={9–16} }